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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHEK2
All Species:
34.55
Human Site:
S357
Identified Species:
54.29
UniProt:
O96017
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O96017
NP_001005735.1
543
60915
S357
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
Chimpanzee
Pan troglodytes
XP_001172779
543
60866
S357
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
Rhesus Macaque
Macaca mulatta
XP_001102484
543
60923
S357
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
Dog
Lupus familis
XP_543464
544
61233
S358
P
E
N
V
L
L
S
S
Q
K
E
D
C
L
I
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z265
546
61070
S361
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
Rat
Rattus norvegicus
NP_446129
545
60912
S360
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508699
537
60493
S335
P
E
N
V
L
L
S
S
H
E
E
N
C
L
I
Chicken
Gallus gallus
NP_001073576
522
58779
S334
P
E
N
V
L
L
S
S
S
E
E
T
C
L
I
Frog
Xenopus laevis
NP_001082016
517
58243
S329
P
E
N
V
L
L
S
S
T
S
E
E
C
C
I
Zebra Danio
Brachydanio rerio
Q501V0
422
47914
L251
R
K
K
G
D
E
C
L
M
K
T
T
C
G
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O61267
476
54243
P306
I
T
H
R
D
L
K
P
D
N
V
L
L
E
T
Honey Bee
Apis mellifera
XP_624334
480
54300
A310
S
N
S
D
I
T
L
A
K
V
S
D
F
G
L
Nematode Worm
Caenorhab. elegans
Q9U1Y5
476
53320
N306
H
R
D
I
K
P
E
N
I
L
C
S
D
K
A
Sea Urchin
Strong. purpuratus
XP_794585
480
52849
D309
E
N
L
L
L
M
S
D
D
K
E
T
I
L
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39009
513
58614
I338
P
E
N
I
L
L
N
I
T
R
R
E
N
P
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99
89.3
N.A.
83.1
83.4
N.A.
74.4
67.5
59.6
28.1
N.A.
34
37.2
30.2
43.2
Protein Similarity:
100
99.8
99
93
N.A.
89.7
89.9
N.A.
82.1
77.9
73.1
41.9
N.A.
51.5
54.5
49.5
58.3
P-Site Identity:
100
100
100
93.3
N.A.
100
100
N.A.
86.6
86.6
73.3
6.6
N.A.
6.6
6.6
0
26.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
93.3
86.6
80
20
N.A.
13.3
40
20
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
7
% A
% Cys:
0
0
0
0
0
0
7
0
0
0
7
0
67
7
0
% C
% Asp:
0
0
7
7
14
0
0
7
14
0
0
47
7
0
0
% D
% Glu:
7
67
0
0
0
7
7
0
0
47
67
14
0
7
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% F
% Gly:
0
0
0
7
0
0
0
0
0
0
0
0
0
14
0
% G
% His:
7
0
7
0
0
0
0
0
7
0
0
0
0
0
0
% H
% Ile:
7
0
0
14
7
0
0
7
7
0
0
0
7
0
60
% I
% Lys:
0
7
7
0
7
0
7
0
7
20
0
0
0
7
7
% K
% Leu:
0
0
7
7
74
74
7
7
0
7
0
7
7
60
7
% L
% Met:
0
0
0
0
0
7
0
0
7
0
0
0
0
0
0
% M
% Asn:
0
14
67
0
0
0
7
7
0
7
0
7
7
0
0
% N
% Pro:
67
0
0
0
0
7
0
7
0
0
0
0
0
7
0
% P
% Gln:
0
0
0
0
0
0
0
0
40
0
0
0
0
0
0
% Q
% Arg:
7
7
0
7
0
0
0
0
0
7
7
0
0
0
0
% R
% Ser:
7
0
7
0
0
0
67
60
7
7
7
7
0
0
7
% S
% Thr:
0
7
0
0
0
7
0
0
14
0
7
20
0
0
14
% T
% Val:
0
0
0
60
0
0
0
0
0
7
7
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _